Researcher biography
James is a qualified dual specialist in Medical Oncology and General and Acute Medicine. He is currently appointed as a Medical Oncology Research Fellow in the Division of Cancer Services, Princess Alexandra Hospital. His clinical interests include geriatric oncology and lung cancer.
James is a PhD student with the Faculty of Medicine. He is investigating frailty in older adults with cancer. Specifically, he is evaluating the measurement, management and mitigation of frailty in this setting.
Journal Articles
Fletcher, James A., Mullally, William J., Ladwa, Rahul and O’Byrne, Kenneth J. (2024). Lorlatinib following alectinib-induced pneumonitis: a case report. JTO Clinical and Research Reports, 5 (2) 100591, 1-5. doi: 10.1016/j.jtocrr.2023.100591
Fletcher, J., Reid, N., Hubbard, R.E., Berry, R., Weston, M., Walpole, E., Kimberley, R., Thaker, D.A. and Ladwa, R. (2024). Frailty Index, Not Age, Predicts Treatment Outcomes and Adverse Events for Older Adults with Cancer. Journal of Frailty & Aging, 1-8. doi: 10.14283/jfa.2024.22
Fletcher, J., Mullally, W.J., Berman, C., Ladwa, R., Xu, W. and O'Byrne, K. (2023). EP11.03-20 Real World Experience of First Line Pembrolizumab for Non-Small Cell Lung Cancer (NSCLC) at a Tertiary Centre. Journal of Thoracic Oncology, 18 (11), S628-S629. doi: 10.1016/j.jtho.2023.09.1192
Pringle, N., Fletcher, J.A., Morton, C., Mullally, W.J., Arneil, M., O'Byrne, K. and Xu, W. (2023). EP08.02-03 Real World Experience of Survival Outcomes in Consolidative Durvalumab in Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC). Journal of Thoracic Oncology, 18 (11), S569. doi: 10.1016/j.jtho.2023.09.1067
Fletcher, J., Pringle, N., Mullally, W., O'Byrne, K., Xu, W. and Ladwa, R. (2023). EP08.02-02 Real World Chemoradiotherapy Outcomes for Frail Older Adults with Unresectable Stage III Non Small Cell Lung Cancer (NSCLC). Journal of Thoracic Oncology, 18 (11), S568. doi: 10.1016/j.jtho.2023.09.1066
Fletcher, James A., Logan, Benignus, Reid, Natasha, Gordon, Emily H., Ladwa, Rahul and Hubbard, Ruth E. (2023). How frail is frail in oncology studies? A scoping review. BMC Cancer, 23 (1) 498, 498. doi: 10.1186/s12885-023-10933-z
Kang, Sebastian, Fletcher, James, Htut, Saw, Brown, Amy, Lyle, Megan, Sabesan, Sabe and Joshi, Abhishek (2023). Administration of immune checkpoint inhibitors at rural towns using the Teleoncology model of care—A North Queensland perspective. Australian Journal of Rural Health, 31 (3), 540-545. doi: 10.1111/ajr.12984
Fletcher, James, Bird, Robert, McLean, Andrew J. W., O’Byrne, Kenneth and Xu, Wen (2022). Acquired haemophilia A secondary to an immune checkpoint inhibitor: a case report. JTO Clinical and Research Reports, 3 (11) 100409, 1-6. doi: 10.1016/j.jtocrr.2022.100409
Fletcher, James, Fox, Sarah, Reid, Natasha, Hubbard, Ruth E. and Ladwa, Rahul (2022). The impact of frailty on health outcomes in older adults with lung cancer: a systematic review. Cancer Treatment and Research Communications, 33 100652, 1-10. doi: 10.1016/j.ctarc.2022.100652
Conference Papers
O'Byrne, K., Shanmugasundaram, K.B., Ahmed, E., Kulasinghe, A., Monkman, J., Fletcher, J.A., Mainwaring, P.N., Masud, M.K., Park, H., Hossain, M.S.A., Yamauchi, Y., Sina, A.A.I., Wuethrich, A. and Trau, M. (2023). Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLC. 2023 World Conference on Lung Cancer, Singapore, 9-12 September 2023. New York, NY United States: Elsevier. doi: 10.1016/j.jtho.2023.09.432
Htut, Saw, Fletcher, James, Lyle, Megan, Rainey, Natalie, Lui, Andrew and Pandey, Ritwik (2020). Retrospective study on Hepatitis B screening and risk of HBV reactivation in immune checkpoint inhibitor therapy for advanced cancer patients. COSA's 47th Annual Scientific Meeting, Quality and Safety, Implementation Science, Cardio‐Oncology, Virtual, Australia, 11-13 November 2020. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.13498
Htut, Saw, Fletcher, James, Lyle, Megan, Rainey, Natalie, Lui, Andrew and Pandey, Ritwik (2020). Retrospective study on Pneumocystis jirovecii Pneumonia (PJP) prophylaxis in advanced cancer patients requiring immunosuppression from immune-related adverse events.. COSA's 47th Annual Scientific Meeting, Quality and Safety, Implementation Science, Cardio‐Oncology, 11–13 November 2020, Virtual, Australia, 11-13 November 2020. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.13498
Hossain, Tasafin, Htut, Saw, Pathmanathan, Shivanshan, Fletcher, James, Pandey, Ritwik, Lui, Andrew, Lyle, Megan and Rainey, Natalie (2020). Do antibiotics reduce survival in patients with advanced non-small cell lung cancer treated with immunotherapy?. Medical Oncology Group of Australia Annual Scientific Meeting, Virtual, Australia, 14-21 August 2020. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
Hossain, Tasafin, Htut, Saw, Pathmanathan, Shivanshan, Fletcher, James, Pandey, Ritwik, Lui, Andrew, Lyle, Megan and Rainey, Natalie (2020). Immunotherapy efficacy and concomitant proton pump inhibitor use in non-small cell lung cancer. Medical Oncology Group of Australia Annual Scientific Meeting, Virtual, Australia., 14-21 August 2020. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
O'Leary, Connor, Fletcher, James, Yuile, Alexander, Xu, Wen, Ladwa, Rahul, McGrath, Margaret, Pavlakis, Nick, Hughes, Brett, McCaffery, Elizabeth and O'Byrne, Kenneth (2020). Limited benefit of adjuvant chemotherapy in resected Epidermal Growth Factor Receptor (EGFR) positive non-small cell lung cancer (NSCLC). Medical Oncology Group of Australia Annual Scientific Meeting, Virtual, Australia, 14-21 August 2020. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
Hossain, Tasafin, Htut, Saw, Pathmanathan, Shivanshan, Fletcher, James, Pandey, Ritwik, Lui, Andrew, Lyle, Megan and Rainey, Natalie (2020). Corticosteriods use and immunotherapy efficacy in patients with non-small cell lung cancer: experience in a regional cancer center. Medical Oncology Group of Australia Annual Science Meeting 2020, Virtual, Australia, 14 - 21 August 2020. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing . doi: 10.1111/ajco.13417
Hossain, Tasafin, Htut, Saw, Pathmanathan, Shivanshan, Fletcher, James, Pandey, Ritwik, Lui, Andrew, Lyle, Megan and Rainey, Natalie (2020). Do proton pump inhibitors affect survival in patients with non-small cell lung cancer treated with immune check point inhibitors?. Medical Oncology Group of Australia Annual Scientific Meeting, Virtual Conference, Australia, 14-21 August 2020. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
Fletcher, James, Kang, Katherine, Smallwood, Gabriella, Sanmugarajah, Jasotha and Lyle, Megan (2020). Mortality within 30 days of receiving checkpoint inhibitor immunotherapy: an Australian multicenter review. 2020 ASCO Annual Meeting, Online, 29-31 May 2020. Alexandria, VA United States: American Society of Clinical Oncology. doi: 10.1200/jco.2020.38.15_suppl.e19182
Fletcher, James, Kang, Sebastian, Brown, Amy, Sabesan, Sabe S., Lyle, Megan, Pandey, Ritwik, Lui, Andrew, Rainey, Natalie, Kelly, Barbara, Schmidt, Andrew Lachlan and Joshi, Abhishek Jagdish (2020). Administration of immune checkpoint inhibitors using teleoncology model of care in Far North Queensland: A multicenter review of safety outcomes. 2020 ASCO Annual Meeting, Online, 29 – 31 May 2020. Alexandria, VA United States: American Society of Clinical Oncology (ASCO). doi: 10.1200/jco.2020.38.15_suppl.2084
Fletcher, James, Kang, Sebastian, Brown, Amy, Sabesan, Sabe S., Lyle, Megan, Pandey, Ritwik, Lui, Andrew, Rainey, Natalie, Kelly, Barbara, Schmidt, Andrew Lachlan and Joshi, Abhishek Jagdish (2020). Administration of immune checkpoint inhibitors using teleoncology model of care in Far North Queensland: A multicenter review of safety outcomes. Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Electr Network, 29-31 May 2020. Alexandria, VA, United States: American Society of Clinical Oncology.
Fletcher, James, Htut, Saw, Kang, Katherine and Lyle, Megan (2019). Survival outcomes for BRAF wild-type advanced melanoma treated with first line immunotherapy in a regional cancer centre: Experience from the Liz Plummer Cancer Centre. COSA's 46th Annual Scientific Meeting, Urological cancer; Age and gender in cancer practice, Adelaide, SA, Australia, 12-14 November 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
Fletcher, James, Kang, Katherine and Lyle, Megan (2019). Mortality within 30 days of receiving checkpoint inhibitor immunotherapy in an Australian regional cancer centre. COSA's 46th Annual Scientific Meeting, Urological cancer; Age and gender in cancer practice, Adelaide, SA, Australia, 12-14 November 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/ajco.13263
Fletcher, James, Marukawa, Mutsuki and Pandey, Ritwik (2019). A single centre retrospective analysis of immunotherapy outcomes for patients with non-small cell lung cancer (NSCLC) . COSA's 46th Annual Scientific Meeting, Urological cancer; Age and gender in cancer practice, Adelaide, SA, Australia, 12-14 November 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
Jakobsson, Haakan, Wood, Samuel, Fletcher, James, Azer, Mary, Francesconi, Alessandra, Houston, Kathleen, Long, Jeremy, Manders, Peter, Morris, Michelle, Wilson, Jennifer and Chan, Bryan A. (2018). Improving the rate of documented patient consent for systemic therapy at a tertiary cancer care centre: a quality improvement project from the Sunshine Coast University Hospital. COSA's 45th Annual Scientific Meeting, Mesothelioma and Gastro‐Intestinal Cancers: Technology and Genomics, Perth, WA, Australia, 13 - 15 November 2018. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.
Fletcher, James, Forbes, Curtis, Cooper, Victoria, McAndrew, Alastair, Turner, Cassie and Chan, Bryan A. (2018). Review of the integrated exercise physiology (EP) clinic at a tertiary cancer centre: experience from the ADEM crosby centre, Sunshine Coast University Hospital (SCUH). COSA's 45th Annual Scientific Meeting, Perth, WA, Australia, 13 - 15 November 2018. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.
Fletcher, James, Sanmugarajah, Jasotha, Caird, Susan, Allen, Michael, Quennell, Amanda and Powell, Michael (2017). Assessing Treatment Tolerability after Geriatric Assessment in the Senior Oncology Clinic at the Gold Coast University Hospital. COSA's 44th Annual Scientific Meeting, Immunotherapy: Molecules and Mountains, Sydney, NSW Australia, 13–15 November 2017. Richmond, VIC Australia: Wiley-Blackwell.
Fletcher, James, Allan, Suzanne and Hill, Andrew (2017). Retrospective Single Institution Audit of the Tolerability and Efficacy of Enzalutamide in Patients with Castrate Refractory Metastatic Prostate Cancer in a Community Oncology Setting. COSA's 44th Annual Scientific Meeting, Immunotherapy: Molecules and Mountains, Sydney, NSW Australia, 13–15 November 2017. Richmond, VIC Australia: Wiley-Blackwell.